AMD EPYC 4345P 8c/16t 3.8GHz-5.3GHz 65W (100-000001556)

AMD EPYC 4345P Server CPU

Positioning and target workloads

AMD EPYC 4345P is an 8-core, single-socket server processor from the EPYC 4005 generation, based on Zen 5 CPU cores and the AM5 platform. It represents a generational step forward from Zen 4–based models, focusing on higher instructions-per-clock efficiency and improved behavior under mixed workloads. This SKU is aimed at edge servers, branch infrastructure, and compact enterprise systems where predictable performance, platform longevity, and modern I/O are required.

Core architecture, frequencies, and cache behavior

The processor features 8 cores and 16 threads with a 3.8 GHz base frequency and boost clocks up to 5.3 GHz. Zen 5 cores bring architectural improvements in execution efficiency, branch handling, and instruction throughput, which translate into better real-world performance at similar clock speeds. With 32 MB of L3 cache, EPYC 4345P supports workloads with moderate shared datasets, helping reduce memory latency for application servers, middleware, and service-oriented architectures. The 65 W TDP allows sustained operation in compact chassis while maintaining stable boost behavior.

Memory subsystem and workload alignment

EPYC 4345P supports dual-channel DDR5 memory at speeds up to DDR5-5600. This higher memory frequency improves per-core bandwidth and helps balance the increased execution capability of Zen 5 cores. Optimal results are achieved through symmetric DIMM population and capacity planning aligned with cache size and workload locality.

PCIe Gen 5 connectivity and expansion planning

The processor provides up to 28 PCI Express Gen 5 lanes, enabling direct attachment of high-speed NVMe storage and modern network adapters. In typical designs, some lanes may be allocated to a chipset to extend I/O capabilities, so careful lane planning is recommended for compact and edge-focused systems.

Platform-level features for professional environments

EPYC 4345P integrates AMD’s Secure Processor to support hardware-based security features. Depending on motherboard implementation, integrated graphics can be used for basic console access, simplifying deployment and management in headless server environments. The AM5 ecosystem also supports modern board-level connectivity and long-term platform stability.

Ideal deployment scenarios

This processor is well suited for edge compute nodes, application and API servers, container orchestration workers, CI/CD runners, and virtualization hosts with moderate consolidation ratios. EPYC 4345P is an effective choice when Zen 5 efficiency, DDR5-5600 memory support, and PCIe Gen 5 connectivity are required within a low-power, single-socket platform.